 KEARNY,
NJ, NOV. 5, 2002--Pharmachem Laboratories,
Inc., today announced that a Chronic Toxicity Study
(L.D.50) demonstrated that Phase 2 Starch Neutralizer™,
the first standardized white bean extract used in a
variety of weight loss supplements, is safe and non-toxic.
“Phase 2® showed
no signs of chronic toxicity at doses up to 1.0 gm/kg
body
weight for up to 90 days,” said Ramadasan Kuttan,
Ph.D., director, Amala Cancer Research Center, Thrissur,
India, who conducted the study along with R. C. Srimal,
M.D. “The data indicates that administration
of Phase 2® for 90 days did not produce
any adverse reaction as seen from the organ weight,
necropsy, haematological values and biochemical values.”
 Additional findings of the study were as
follows:
• There was no significant weight changes in
any of the animals.
• Food consumption in the Phase 2® groups (1 gm and 5 gm) was found to be decreased significantly,
especially after two months of treatment, compared to
controls.
• Liver function tests indicated that chronic administration
of Phase 2® at the doses given did not
produce any change in the liver function tests such as
GOT, GPT, ALP, Bilirubin, total protein and Albumin/Globulin
ratio.
• Chronic administration of the Phase 2® did not produce any change in the renal function as indicated
from serum urea, creatinine and electrolyte levels.
• Chronic administration of Phase 2® did not produce any change in the haematological parameters
such as total WBC, differential count and platelets.
• There was no change in necroscopy of the
animals and organ weight of the animals such as liver,
kidney, spleen were unchanged.
• There was no significant change in the lipid profile
of animals treated with Phase 2®
• Histopathology of liver and kidney of the Phase 2® -treated groups was normal and similar
to controls.
An LD 50 study for acute
toxicity, conducted earlier this year, also confirmed
that Phase 2® is “safe
and non-toxic.”
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